General information about Tamoxifen in the UK
Tamoxifen is a nonsteroidal anti-estrogen agent having also weak estrogenic properties. Its action is based on the ability to block estrogen receptors. Tamoxifen, as well as some of its metabolites, estradiol compete for binding sites with cytoplasmic estrogen receptors in breast tissue, uterus, vagina, pituitary gland tumor and with a high content of estrogen receptors. In contrast to estrogen receptor complex receptor complex tamoxifen does not stimulate DNA synthesis in the nucleus and inhibits cell division, leading to regression.
Tamoxifen, indications for use
Breast cancer (estrogen-dependent), anovulatory infertility, certain types of male infertility.
Dosing and Administration
Inside, in breast cancer - 10-20 mg two times a day (at the rate - 2,4-9,6 g); treatment should be continued for 1-2 months after the onset of symptoms of the regression process.
Dyspepsia, dizziness, edema, leukopenia, thrombocytopenia, hypercalcemia, keratopathy, retinopathy, dysmenorrhoea, hot flushes, metrorrhagia, itching of the vulva, reversible cystic ovarian swelling.