General information about Andriol in the UK
Andriol - a hormonal drug comprises testosterone in its composition. Testosterone - it is an endogenous hormone, necessary for the normal development of male sex organs and secondary sex characteristics, in order to maintain the normal function of the testicles, prostate and seminal vesicles, the maintenance of libido and potency. In the UK use of the drug for the treatment of hypogonadism in men results in a clinically significant increase in the plasma concentration of testosterone, dihydrotestosterone, and androstenedione and a reduction of sex hormone binding globulin (SHBG). In males with primary (hypergonadotrophic) hypogonadism use of the drug leads to a normalization of gonadotropin concentrations.
Testosterone undecanoate + auxiliaries.
After ingestion Andriol significant part together with a lipophilic solvent absorbed in the intestine and enters the lymphatic system thus avoiding first pass through the liver. After absorption of testosterone undecanoate partly reduced to form dihydrotestosterone undecanoate. it enters into the plasma from the lymphatic system. In plasma and tissues as a result of hydrolysis of testosterone undecanoate and ditdrotestosterona undecanoate released natural male sex hormones testosterone and dihydrotestosterone. A single dose of 80-160 mg Andriol leads to a clinically significant increase in total plasma testosterone concentration, Cmax is approximately 40 nmol / l is reached within 4-5 hours after ingestion. Increased testosterone concentration is maintained, but at least for 8 hours. Shown mainly in the urine as conjugates (etioholanolon and androsterone).