Pharmacological effects - antibacterial, bacteriostatic, broad-spectrum antibacterial.
Blocks protein synthesis in cells of microorganisms.
It is active against gram-positive cocci (S.aureus), coagulase-negative staphylococci, streptococci (S.pneumoniae, S.pyogenes - Group A, S.agalactiae - Group B, S.viridans, A.israelii strains, B.anthracis, L. monocytogenes ), Gram-negative cocci (N.meningitidis, N.gonorrhoeae, B.catarrhalis), sticks (Bordetella, Brucella spp., Calymmatobacterium granulomatis, Campylobacter spp., F.tularensis, H.influenzae, H.ducreyi, Legionella, P.multocida , Yersinia spp.), Vibrionaceae strains (V.cholerae, V.parahaemolyticus), et al. microorganisms (Helicobacter pylori, Chlamydia spp., Rickettsia spp., Coxiella spp.), spirochetes (Borrelia burgdorferi, Leptospira interrogans, Treponema pallidum), Mycobacterium spp., Mycoplasma pneumoniae, Ureaplasma urealyticum, and protozoa (Plasmodium falciparum, Entamoeba histolytica).
Enough is well absorbed from the gastrointestinal tract. Associated with the blood supply by 80-90%. Readily soluble in fats and easily penetrates into the biological fluids, including aqueous humor and the tissue. T1 / 2 -. 15-25 h Most of the output from the faeces, approximately 40% - in the urine.
Indications in the UK Doxycycline drug
Bacterial infections of the respiratory tract and urinary tract, cholecystitis, tonsillitis, sinusitis, skin and soft tissue infections, Lyme disease, gonorrhea, syphilis; infections caused by chlamydia, mycoplasma, rickettsia; brucellosis, tularemia.
Hypersensitivity, porphyria, severe liver failure, pregnancy, breast-feeding, the age of 9 years.