General information about Tretizen in the UK
It normalizes the terminal differentiation of the cells, inhibits the proliferation of the epithelium of the sebaceous glands, the formation of detritus, facilitates its evacuation. It reduces the production and facilitates the secretion of sebum.
At intake absorption of volatile, low bioavailability and variable; together with food intake increases the bioavailability of 2 times. Tmax - 2-4 hours Linking plasma proteins (mainly albumin) -. 99.9%. Metabolized to form three major active metabolites - 4-oxo-isotretinoin (major metabolite), tretinoin and 4-oxo-retinoina and less significant metabolites including glucuronides well. As in vivo isotretinoin and tretinoin reversibly transformed into each other, tretinoin metabolism associated with the metabolism of isotretinoin. 20-30% of the dose is metabolized by isomerization of isotretinoin. The pharmacokinetics of isotretinoin in man an essential role can play enterohepatic circulation. In in vitro studies have shown that isotretinoin metabolism are involved isozymes CYP2C8, CYP2C9, CYP3A4 and CYP2B6 P450. T1 / 2 of isotretinoin - 19 h, 4-oxo-izoretinoina -. 29 hours excreted by the kidneys and bile in approximately equal amounts.
Application of the substance Isotretinoin
For oral and rectal administration: severe forms of acne (nodular or cystic, conglobata, acne scarring risk); Acne is not amenable to other therapies.
For topical use: acne vulgaris, seborrheic dermatitis, rosacea, perioral dermatitis.
Contraindications in the UK
Hypersensitivity, oral and rectal use: pregnancy, installed or planned (possible teratogenic and embryotoxic action), the period of breast-feeding, liver failure, hypervitaminosis A, expressed hyperlipidemia, concomitant tetracycline therapy; for rectal administration (optional): diseases of the rectum; for topical application: Do not apply over large areas of the skin during pregnancy, breastfeeding and women planning pregnancy.
For regular use: diabetes, a history of depression, obesity, lipid metabolism, alcoholism.