General information about Frusenex in the UK
Mode of action - a diuretic.
Blocks the reabsorption of sodium and chloride in the ascending loop of Henle knee. It increases excretion of potassium, calcium, magnesium.
When ingestion bioavailability is 64%. Cmax increased with increasing dose, but the time did not achieve maximum dose-dependent and varies widely depending on the condition of the patient. T1 / 2 -. About 2 h 91-99% associated plasma protein, 2,4-4,1% is in the free state. Biotransformiroetsa, mainly in the glucuronide. Return with urine (after the on / in more than ingestion).
Starting diuretic effect ingestion is observed within 1 hour, most of action - in 1-2 hours duration -. 6.8 h on / in the introduction of onset of action - 5 min, max - 30 minutes duration - about 2 hours. The on / in the introduction causes varicose veins, quickly reducing preload reduces the pressure in the left ventricle and the pulmonary artery, reduces the system pressure.
Indications Lasix medication
Edematous syndrome of various genesis (heart, liver, kidney after the second month of pregnancy, intoxication), lung and brain edema, hypertension, forced diuresis, renal failure.
Hypersensitivity (including to other. Sulfon- and sulfonamides), acute glomerulonephritis, renal failure with anuria, hepatic coma, disruption of water and electrolyte balance and acid-base balance (hypokalaemia, hyponatraemia).
Pregnancy and breast-feeding
If pregnancy should be used under strict indications and only for a short time. At the time of treatment is necessary to suspend breastfeeding.
Hypotension, arrhythmia, dry mouth, nausea, vomiting, diarrhea, pancreatitis, hypovolemia, dehydration, hypokalemia, hyponatremia, hyposalemia, metabolic alkalosis, hypocalcemia, hyperuricemia, dermatitis, hearing loss, vision, paresthesia, dizziness, muscle weakness, urinary retention in patients with BPH, hypercholesterolemia, hypertriglyceridemia, impaired glucose tolerance, acute pancreatitis, and allergic reactions (rash, fever, vasculitis, interstitial nephritis); in preterm infants - nephrocalcinosis.
It increases the risk of cardiac glycoside intoxication (in the background of glucocorticoids probability hypokalemia), nephrotoxicity and ototoxic effects of aminoglycosides, cephalosporins, cisplatin; enhances the effect of curariform funds; increase lithium reabsorption in the renal tubules. NSAIDs reduce the diuretic effect.